TargetNet
P35557
Glucokinase
Function
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Database Links
| Database | Links |
|---|---|
| UniProt | P35557 |
| PDB | 1GLK, 1V4S, 1V4T, 3A0I, 3F9M, 3FGU, 3FR0, 3GOI, 3H1V, 3ID8, 3IDH, 3IMX, 3QIC, 3S41, 3VEV, 3VEY, 3VF6, 4DCH, 4DHY, 4ISE, 4ISF, 4ISG, 4IWV, 4IXC, 4L3Q, 4LC9, 4MLE, 4MLH |
| BioGrid | 108915 |
| BindingDB | P35557 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA28610 |
| KEGG | hsa:2645 |
| BioCyc | MetaCyc:HS02935-MONOMER |
| Entrez Gene (GeneID) | 2645 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9646 | 0.0023 |
| Accuracy | 0.9273 | 0.0047 |
| Sensitivity | 0.9515 | 0.0049 |
| Specificity | 0.9007 | 0.0064 |
| BEDROC | 0.9637 | 0.0145 |
| MCC Threshold | 0.39 | N/A |
| MCC | 0.862 | N/A |
| F-score Threshold | 0.39 | N/A |
| F-score | 0.9358 | N/A |