Q9Y5Z0

Beta-secretase 2

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Database Links

Database	Links
UniProt	Q9Y5Z0
PDB	2EWY, 3ZKG, 3ZKI, 3ZKM, 3ZKN, 3ZKQ, 3ZKS, 3ZKX, 3ZL7, 3ZLQ, 4BEL, 4BFB
BioGrid	117353
BindingDB	Q9Y5Z0
DrugBank	Not available
Guide to PHARMACOLOGY	2331
PharmGKB	PA25233
KEGG	hsa:25825
BioCyc	MetaCyc:G66-33964-MONOMER
Entrez Gene (GeneID)	25825

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9667	0.0019
Accuracy	0.9072	0.0062
Sensitivity	0.9147	0.01
Specificity	0.9002	0.0065
BEDROC	0.9923	0.0084
MCC Threshold	0.36	N/A
MCC	0.8317	N/A
F-score Threshold	0.36	N/A
F-score	0.9146	N/A

Downloads

R Model Object

Random Forest model object (.RData)

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Positive Set

SMILES string + affinity value (.tsv)

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TargetNet