TargetNet
Q9Y5Y4
Prostaglandin D2 receptor 2
Function
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9Y5Y4 |
| PDB | Not available |
| BioGrid | 116412 |
| BindingDB | Q9Y5Y4 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 339 |
| PharmGKB | PA28891 |
| KEGG | hsa:11251 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 11251 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9857 | 5.1438 × 10-4 |
| Accuracy | 0.9643 | 0.0036 |
| Sensitivity | 0.9602 | 0.0066 |
| Specificity | 0.9685 | 0.0019 |
| BEDROC | 0.9944 | 0.0037 |
| MCC Threshold | 0.462 | N/A |
| MCC | 0.9491 | N/A |
| F-score Threshold | 0.462 | N/A |
| F-score | 0.9748 | N/A |