TargetNet
Q9Y5X4
Photoreceptor-specific nuclear receptor
Function
Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9Y5X4 |
| PDB | Not available |
| BioGrid | 115320 |
| BindingDB | Q9Y5X4 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA31757 |
| KEGG | hsa:10002 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 10002 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7935 | 0.0113 |
| Accuracy | 0.7059 | 0.0197 |
| Sensitivity | 0.75 | 0.0257 |
| Specificity | 0.6628 | 0.0187 |
| BEDROC | 0.8839 | 0.0315 |
| MCC Threshold | 0.372 | N/A |
| MCC | 0.5137 | N/A |
| F-score Threshold | 0.372 | N/A |
| F-score | 0.7756 | N/A |