TargetNet
Q9Y5N1
Histamine H3 receptor
Function
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9Y5N1 |
| PDB | Not available |
| BioGrid | 116416 |
| BindingDB | Q9Y5N1 |
| DrugBank | DB00667 |
| Guide to PHARMACOLOGY | 264 |
| PharmGKB | PA29458 |
| KEGG | hsa:11255 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 11255 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9907 | 4.8029 × 10-4 |
| Accuracy | 0.9673 | 0.0016 |
| Sensitivity | 0.9696 | 0.0027 |
| Specificity | 0.9653 | 0.0022 |
| BEDROC | 0.992 | 0.0018 |
| MCC Threshold | 0.552 | N/A |
| MCC | 0.9375 | N/A |
| F-score Threshold | 0.552 | N/A |
| F-score | 0.9665 | N/A |