TargetNet
Q9Y2R2
Tyrosine-protein phosphatase non-receptor type 22
Function
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9Y2R2 |
| PDB | 2P6X, 2QCJ, 2QCT, 3BRH, 3H2X, 3OLR, 3OMH, 4J51 |
| BioGrid | 117604 |
| BindingDB | Q9Y2R2 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33995 |
| KEGG | hsa:26191 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 26191 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8489 | 0.0103 |
| Accuracy | 0.7775 | 0.0122 |
| Sensitivity | 0.7152 | 0.0178 |
| Specificity | 0.8343 | 0.0243 |
| BEDROC | 0.9748 | 0.0071 |
| MCC Threshold | 0.508 | N/A |
| MCC | 0.5728 | N/A |
| F-score Threshold | 0.466 | N/A |
| F-score | 0.7724 | N/A |