TargetNet
Q9Y271
Cysteinyl leukotriene receptor 1
Function
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9Y271 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q9Y271 |
| DrugBank | DB01025, DB00587, DB00471, DB00716, DB01411, DB00549 |
| Guide to PHARMACOLOGY | 269 |
| PharmGKB | PA38453 |
| KEGG | hsa:10800 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 10800 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9934 | 0.001 |
| Accuracy | 0.9716 | 0.0019 |
| Sensitivity | 0.9639 | 0.0034 |
| Specificity | 0.9782 | 0.0028 |
| BEDROC | 0.9998 | 9.9152 × 10-5 |
| MCC Threshold | 0.456 | N/A |
| MCC | 0.9454 | N/A |
| F-score Threshold | 0.456 | N/A |
| F-score | 0.9707 | N/A |