TargetNet
Q9Y233
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9Y233 |
| PDB | 1LRB, 2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 4AEL, 4AJD, 4AJF, 4AJG, 4AJM, 4BBX, 4DDL, 4DFF, 4FCB, 4FCD, 4HEU, 4HF4, 4MUW, 4MVH |
| BioGrid | 116057 |
| BindingDB | Q9Y233 |
| DrugBank | DB00975 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33120 |
| KEGG | hsa:10846 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 10846 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9913 | 4.3811 × 10-4 |
| Accuracy | 0.9696 | 0.0021 |
| Sensitivity | 0.9703 | 0.0022 |
| Specificity | 0.9687 | 0.004 |
| BEDROC | 0.9995 | 5.1723 × 10-4 |
| MCC Threshold | 0.498 | N/A |
| MCC | 0.9403 | N/A |
| F-score Threshold | 0.446 | N/A |
| F-score | 0.9733 | N/A |