ATP-binding cassette sub-family G member 2
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Database | Links |
---|---|
UniProt | Q9UNQ0 |
PDB | Not available |
BioGrid | 114821 |
BindingDB | Q9UNQ0 |
DrugBank | DB00619, DB01204, DB00622, DB01054, DB01098, DB01232, DB01030 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA390 |
KEGG | hsa:9429 |
BioCyc | Not available |
Entrez Gene (GeneID) | 9429 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.8557 | 0.0087 |
Accuracy | 0.7885 | 0.0123 |
Sensitivity | 0.7182 | 0.0211 |
Specificity | 0.8477 | 0.0166 |
BEDROC | 0.948 | 0.0261 |
MCC Threshold | 0.522 | N/A |
MCC | 0.5939 | N/A |
F-score Threshold | 0.41 | N/A |
F-score | 0.7654 | N/A |