TargetNet
Q9UBN7
Histone deacetylase 6
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9UBN7 |
| PDB | 3C5K, 3GV4, 3PHD |
| BioGrid | 115330 |
| BindingDB | Q9UBN7 |
| DrugBank | DB02546 |
| Guide to PHARMACOLOGY | 2618 |
| PharmGKB | PA29231 |
| KEGG | hsa:10013 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 10013 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9653 | 0.0015 |
| Accuracy | 0.93 | 0.0033 |
| Sensitivity | 0.9253 | 0.0067 |
| Specificity | 0.9346 | 0.0035 |
| BEDROC | 0.9841 | 0.0045 |
| MCC Threshold | 0.46 | N/A |
| MCC | 0.8736 | N/A |
| F-score Threshold | 0.46 | N/A |
| F-score | 0.9361 | N/A |