TargetNet
Q9NZ42
Gamma-secretase subunit PEN-2
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9NZ42 |
| PDB | Not available |
| BioGrid | 120953 |
| BindingDB | Q9NZ42 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA142671122 |
| KEGG | hsa:55851 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 55851 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9741 | 0.0019 |
| Accuracy | 0.9314 | 0.0072 |
| Sensitivity | 0.9304 | 0.005 |
| Specificity | 0.9322 | 0.0113 |
| BEDROC | 0.9835 | 0.0096 |
| MCC Threshold | 0.408 | N/A |
| MCC | 0.8812 | N/A |
| F-score Threshold | 0.408 | N/A |
| F-score | 0.9367 | N/A |