TargetNet
Q9NR96
Toll-like receptor 9
Function
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9NR96 |
| PDB | Not available |
| BioGrid | 119902 |
| BindingDB | Q9NR96 |
| DrugBank | DB00608 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA38010 |
| KEGG | hsa:54106 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 54106 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7583 | 0.0128 |
| Accuracy | 0.7104 | 0.0109 |
| Sensitivity | 0.7427 | 0.0161 |
| Specificity | 0.6748 | 0.023 |
| BEDROC | 0.8631 | 0.0386 |
| MCC Threshold | 0.512 | N/A |
| MCC | 0.4149 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.736 | N/A |