TargetNet
Q9HC97
G-protein coupled receptor 35
Function
Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9HC97 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q9HC97 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 102 |
| PharmGKB | PA28880 |
| KEGG | hsa:2859 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2859 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8675 | 0.0083 |
| Accuracy | 0.8127 | 0.0092 |
| Sensitivity | 0.8416 | 0.0124 |
| Specificity | 0.7804 | 0.0164 |
| BEDROC | 0.9379 | 0.0138 |
| MCC Threshold | 0.394 | N/A |
| MCC | 0.6525 | N/A |
| F-score Threshold | 0.394 | N/A |
| F-score | 0.8456 | N/A |