DNA dC->dU-editing enzyme APOBEC-3G
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Database | Links |
---|---|
UniProt | Q9HC16 |
PDB | 2JYW, 2KBO, 2KEM, 3E1U, 3IQS, 3IR2, 3V4J, 3V4K |
BioGrid | 121920, 128319 |
BindingDB | Q9HC16 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA24897 |
KEGG | hsa:60489 |
BioCyc | Not available |
Entrez Gene (GeneID) | 60489 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.8356 | 0.0067 |
Accuracy | 0.7594 | 0.0096 |
Sensitivity | 0.7393 | 0.0146 |
Specificity | 0.7826 | 0.0137 |
BEDROC | 0.9502 | 0.005 |
MCC Threshold | 0.562 | N/A |
MCC | 0.5279 | N/A |
F-score Threshold | 0.396 | N/A |
F-score | 0.7779 | N/A |