TargetNet
Q9HAZ1
Dual specificity protein kinase CLK4
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9HAZ1 |
| PDB | Not available |
| BioGrid | 121501 |
| BindingDB | Q9HAZ1 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1993 |
| PharmGKB | PA26598 |
| KEGG | hsa:57396 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 57396 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8417 | 0.0082 |
| Accuracy | 0.7645 | 0.0132 |
| Sensitivity | 0.6867 | 0.0171 |
| Specificity | 0.8505 | 0.0257 |
| BEDROC | 0.9506 | 0.0236 |
| MCC Threshold | 0.488 | N/A |
| MCC | 0.5927 | N/A |
| F-score Threshold | 0.366 | N/A |
| F-score | 0.8 | N/A |