TargetNet
Q9H3N8
Histamine H4 receptor
Function
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
Database Links
| Database | Links |
|---|---|
| UniProt | Q9H3N8 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q9H3N8 |
| DrugBank | DB00363 |
| Guide to PHARMACOLOGY | 265 |
| PharmGKB | PA134982275 |
| KEGG | hsa:59340 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 59340 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9712 | 0.0015 |
| Accuracy | 0.9164 | 0.003 |
| Sensitivity | 0.9188 | 0.0025 |
| Specificity | 0.9142 | 0.0044 |
| BEDROC | 0.9989 | 3.8419 × 10-4 |
| MCC Threshold | 0.518 | N/A |
| MCC | 0.8364 | N/A |
| F-score Threshold | 0.434 | N/A |
| F-score | 0.918 | N/A |