TargetNet
Q9H244
P2Y purinoceptor 12
Function
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9H244 |
| PDB | 1T78, 1VZ1, 1Y9C |
| BioGrid | Not available |
| BindingDB | Q9H244 |
| DrugBank | DB00758, DB01240, DB00208, DB00374 |
| Guide to PHARMACOLOGY | 328 |
| PharmGKB | PA134971947 |
| KEGG | hsa:64805 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 64805 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9808 | 0.0015 |
| Accuracy | 0.9347 | 0.0028 |
| Sensitivity | 0.9412 | 0.0059 |
| Specificity | 0.9292 | 0.0026 |
| BEDROC | 0.9961 | 0.0033 |
| MCC Threshold | 0.404 | N/A |
| MCC | 0.8834 | N/A |
| F-score Threshold | 0.404 | N/A |
| F-score | 0.9378 | N/A |