TargetNet
Q9H228
Sphingosine 1-phosphate receptor 5
Function
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9H228 |
| PDB | Not available |
| BioGrid | 119793 |
| BindingDB | Q9H228 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 279 |
| PharmGKB | PA162402378 |
| KEGG | hsa:53637 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 53637 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9606 | 0.0032 |
| Accuracy | 0.9276 | 0.0067 |
| Sensitivity | 0.916 | 0.0114 |
| Specificity | 0.9401 | 0.0062 |
| BEDROC | 0.9983 | 0.0027 |
| MCC Threshold | 0.44 | N/A |
| MCC | 0.8632 | N/A |
| F-score Threshold | 0.44 | N/A |
| F-score | 0.9343 | N/A |