TargetNet
Q9GZU7
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Function
Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Database Links
| Database | Links |
|---|---|
| UniProt | Q9GZU7 |
| PDB | 1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL |
| BioGrid | 121804 |
| BindingDB | Q9GZU7 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA134938848 |
| KEGG | hsa:58190 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 58190 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7911 | 0.0033 |
| Accuracy | 0.7175 | 0.0053 |
| Sensitivity | 0.7368 | 0.0098 |
| Specificity | 0.6969 | 0.0136 |
| BEDROC | 0.894 | 0.0055 |
| MCC Threshold | 0.45 | N/A |
| MCC | 0.4752 | N/A |
| F-score Threshold | 0.416 | N/A |
| F-score | 0.7691 | N/A |