TargetNet
Q99835
Smoothened homolog
Function
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.
Database Links
| Database | Links |
|---|---|
| UniProt | Q99835 |
| PDB | 4JKV, 4N4W |
| BioGrid | 112492 |
| BindingDB | Q99835 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA35968 |
| KEGG | hsa:6608 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6608 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9919 | 0.0021 |
| Accuracy | 0.9716 | 0.0018 |
| Sensitivity | 0.9729 | 0.0034 |
| Specificity | 0.9702 | 0.0028 |
| BEDROC | 0.9999 | 1.7962 × 10-5 |
| MCC Threshold | 0.56 | N/A |
| MCC | 0.9509 | N/A |
| F-score Threshold | 0.56 | N/A |
| F-score | 0.9755 | N/A |