TargetNet
Q99808
Equilibrative nucleoside transporter 1
Function
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Database Links
| Database | Links |
|---|---|
| UniProt | Q99808 |
| PDB | Not available |
| BioGrid | 108344 |
| BindingDB | Q99808 |
| DrugBank | DB00197 |
| Guide to PHARMACOLOGY | 1117 |
| PharmGKB | PA154 |
| KEGG | hsa:2030 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2030 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9826 | 0.0022 |
| Accuracy | 0.9517 | 0.0061 |
| Sensitivity | 0.9593 | 0.0074 |
| Specificity | 0.9446 | 0.0077 |
| BEDROC | 0.9993 | 3.5005 × 10-4 |
| MCC Threshold | 0.474 | N/A |
| MCC | 0.9308 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.9646 | N/A |