TargetNet
Q99685
Monoglyceride lipase
Function
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Database Links
| Database | Links |
|---|---|
| UniProt | Q99685 |
| PDB | 3HJU, 3JW8, 3JWE, 3PE6 |
| BioGrid | 116471 |
| BindingDB | Q99685 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1399 |
| PharmGKB | PA30789 |
| KEGG | hsa:11343 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 11343 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9286 | 0.0084 |
| Accuracy | 0.9006 | 0.0073 |
| Sensitivity | 0.8656 | 0.0126 |
| Specificity | 0.9305 | 0.0091 |
| BEDROC | 0.9455 | 0.0154 |
| MCC Threshold | 0.408 | N/A |
| MCC | 0.8147 | N/A |
| F-score Threshold | 0.408 | N/A |
| F-score | 0.9006 | N/A |