TargetNet
Q99572
P2X purinoceptor 7
Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Database Links
| Database | Links |
|---|---|
| UniProt | Q99572 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q99572 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 484 |
| PharmGKB | PA32866 |
| KEGG | hsa:5027 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5027 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9873 | 0.0012 |
| Accuracy | 0.9586 | 0.0036 |
| Sensitivity | 0.9623 | 0.0055 |
| Specificity | 0.9549 | 0.0028 |
| BEDROC | 0.9912 | 0.0054 |
| MCC Threshold | 0.452 | N/A |
| MCC | 0.929 | N/A |
| F-score Threshold | 0.452 | N/A |
| F-score | 0.9645 | N/A |