TargetNet
Q99500
Sphingosine 1-phosphate receptor 3
Function
Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Database Links
| Database | Links |
|---|---|
| UniProt | Q99500 |
| PDB | Not available |
| BioGrid | 108227 |
| BindingDB | Q99500 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 277 |
| PharmGKB | PA162402362 |
| KEGG | hsa:1903 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1903 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.905 | 0.0041 |
| Accuracy | 0.8396 | 0.0049 |
| Sensitivity | 0.8066 | 0.009 |
| Specificity | 0.8729 | 0.0057 |
| BEDROC | 0.9879 | 0.0047 |
| MCC Threshold | 0.686 | N/A |
| MCC | 0.6813 | N/A |
| F-score Threshold | 0.402 | N/A |
| F-score | 0.8379 | N/A |