TargetNet
Q96RI1
Bile acid receptor
Function
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Database Links
| Database | Links |
|---|---|
| UniProt | Q96RI1 |
| PDB | 1OSH, 1OSK, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3P88, 3P89, 3RUT, 3RUU, 3RVF, 4II6 |
| BioGrid | 115296 |
| BindingDB | Q96RI1 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 603 |
| PharmGKB | PA31752 |
| KEGG | hsa:9971 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 9971 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9833 | 9.8501 × 10-4 |
| Accuracy | 0.9554 | 0.0024 |
| Sensitivity | 0.9592 | 0.0048 |
| Specificity | 0.9511 | 0.0046 |
| BEDROC | 0.9973 | 0.0024 |
| MCC Threshold | 0.416 | N/A |
| MCC | 0.923 | N/A |
| F-score Threshold | 0.416 | N/A |
| F-score | 0.9638 | N/A |