TargetNet
Q96BI3
Gamma-secretase subunit APH-1A
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Database Links
| Database | Links |
|---|---|
| UniProt | Q96BI3 |
| PDB | Not available |
| BioGrid | 119296 |
| BindingDB | Q96BI3 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA142672599 |
| KEGG | hsa:51107 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 51107 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9772 | 0.0038 |
| Accuracy | 0.9378 | 0.0047 |
| Sensitivity | 0.9417 | 0.0055 |
| Specificity | 0.9344 | 0.0084 |
| BEDROC | 0.9981 | 0.0048 |
| MCC Threshold | 0.59 | N/A |
| MCC | 0.8924 | N/A |
| F-score Threshold | 0.59 | N/A |
| F-score | 0.9414 | N/A |