TargetNet
Q92847
Growth hormone secretagogue receptor type 1
Function
Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).
Database Links
| Database | Links |
|---|---|
| UniProt | Q92847 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q92847 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 246 |
| PharmGKB | PA28677 |
| KEGG | hsa:2693 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2693 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9862 | 0.0011 |
| Accuracy | 0.9529 | 0.002 |
| Sensitivity | 0.9574 | 0.0027 |
| Specificity | 0.9491 | 0.0025 |
| BEDROC | 0.998 | 7.8071 × 10-4 |
| MCC Threshold | 0.472 | N/A |
| MCC | 0.9166 | N/A |
| F-score Threshold | 0.472 | N/A |
| F-score | 0.9554 | N/A |