Estrogen receptor beta
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Database | Links |
---|---|
UniProt | Q92731 |
PDB | 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4J26 |
BioGrid | 108404 |
BindingDB | Q92731 |
DrugBank | DB01128, DB00783, DB01196, DB00481, DB00675, DB01108 |
Guide to PHARMACOLOGY | 621 |
PharmGKB | PA27886 |
KEGG | hsa:2100 |
BioCyc | Not available |
Entrez Gene (GeneID) | 2100 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9331 | 0.0016 |
Accuracy | 0.8781 | 0.0024 |
Sensitivity | 0.838 | 0.0031 |
Specificity | 0.9136 | 0.004 |
BEDROC | 0.967 | 0.0039 |
MCC Threshold | 0.602 | N/A |
MCC | 0.7633 | N/A |
F-score Threshold | 0.402 | N/A |
F-score | 0.8709 | N/A |