TargetNet
Q92542
Nicastrin
Function
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Database Links
| Database | Links |
|---|---|
| UniProt | Q92542 |
| PDB | Not available |
| BioGrid | 116961 |
| BindingDB | Q92542 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA142671271 |
| KEGG | hsa:23385 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 23385 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9725 | 0.0036 |
| Accuracy | 0.9266 | 0.0092 |
| Sensitivity | 0.9417 | 0.0086 |
| Specificity | 0.9114 | 0.0138 |
| BEDROC | 0.9893 | 0.0076 |
| MCC Threshold | 0.46 | N/A |
| MCC | 0.8836 | N/A |
| F-score Threshold | 0.46 | N/A |
| F-score | 0.9428 | N/A |