TargetNet
Q8WW43
Gamma-secretase subunit APH-1B
Function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Database Links
| Database | Links |
|---|---|
| UniProt | Q8WW43 |
| PDB | Not available |
| BioGrid | 123659 |
| BindingDB | Q8WW43 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA142672600 |
| KEGG | hsa:83464 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 83464 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9742 | 0.0044 |
| Accuracy | 0.9413 | 0.0067 |
| Sensitivity | 0.9668 | 0.0131 |
| Specificity | 0.9099 | 0.0044 |
| BEDROC | 0.9918 | 0.009 |
| MCC Threshold | 0.418 | N/A |
| MCC | 0.8999 | N/A |
| F-score Threshold | 0.418 | N/A |
| F-score | 0.9558 | N/A |