TargetNet
Q8TDV5
Glucose-dependent insulinotropic receptor
Function
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Database Links
| Database | Links |
|---|---|
| UniProt | Q8TDV5 |
| PDB | Not available |
| BioGrid | 126586 |
| BindingDB | Q8TDV5 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 126 |
| PharmGKB | PA134928131 |
| KEGG | hsa:139760 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 139760 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9838 | 0.0016 |
| Accuracy | 0.9638 | 0.0026 |
| Sensitivity | 0.9766 | 0.0044 |
| Specificity | 0.9505 | 0.0031 |
| BEDROC | 0.998 | 8.8239 × 10-4 |
| MCC Threshold | 0.444 | N/A |
| MCC | 0.9344 | N/A |
| F-score Threshold | 0.444 | N/A |
| F-score | 0.9682 | N/A |