TargetNet
Q8TDU6
G-protein coupled bile acid receptor 1
Function
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
Database Links
| Database | Links |
|---|---|
| UniProt | Q8TDU6 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q8TDU6 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 37 |
| PharmGKB | PA134903170 |
| KEGG | hsa:151306 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 151306 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9594 | 0.0039 |
| Accuracy | 0.8987 | 0.0066 |
| Sensitivity | 0.9299 | 0.0132 |
| Specificity | 0.8689 | 0.0112 |
| BEDROC | 0.9943 | 0.0048 |
| MCC Threshold | 0.328 | N/A |
| MCC | 0.8126 | N/A |
| F-score Threshold | 0.328 | N/A |
| F-score | 0.9063 | N/A |