TargetNet
Q8T6T2
Inosine-5'-monophosphate dehydrogenase
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Database Links
| Database | Links |
|---|---|
| UniProt | Q8T6T2 |
| PDB | 3FFS, 4IXH |
| BioGrid | Not available |
| BindingDB | Q8T6T2 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9967 | 0.001 |
| Accuracy | 0.9792 | 0.0028 |
| Sensitivity | 0.9626 | 0.0064 |
| Specificity | 0.9931 | 0.0022 |
| BEDROC | 1 | 3.7407 × 10-6 |
| MCC Threshold | 0.404 | N/A |
| MCC | 0.9578 | N/A |
| F-score Threshold | 0.394 | N/A |
| F-score | 0.9767 | N/A |