TargetNet
Q8IXJ6
NAD-dependent protein deacetylase sirtuin-2
Function
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins such as ACLY, PCK1 and RELA. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.
Database Links
| Database | Links |
|---|---|
| UniProt | Q8IXJ6 |
| PDB | 1J8F, 3ZGO, 3ZGV |
| BioGrid | 116593 |
| BindingDB | Q8IXJ6 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA35786 |
| KEGG | hsa:22933 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 22933 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8938 | 0.0074 |
| Accuracy | 0.818 | 0.0127 |
| Sensitivity | 0.8225 | 0.0238 |
| Specificity | 0.8138 | 0.0106 |
| BEDROC | 0.9457 | 0.0228 |
| MCC Threshold | 0.576 | N/A |
| MCC | 0.6806 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.8246 | N/A |