TargetNet
Q6B856
Tubulin beta-2B chain
Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q6B856 |
| PDB | 1SA0, 1SA1, 1TVK, 1Z2B, 2P4N, 2XRP, 3DCO, 3DU7, 3E22, 3IZ0, 3J1T, 3J1U, 3J2U, 4AQV, 4AQW, 4ATU, 4ATX, 4I4T, 4I50, 4I55, 4IHJ, 4IIJ |
| BioGrid | 158875 |
| BindingDB | Q6B856 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:281555 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 281555 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8282 | 0.015 |
| Accuracy | 0.7665 | 0.0201 |
| Sensitivity | 0.7953 | 0.0235 |
| Specificity | 0.7341 | 0.0261 |
| BEDROC | 0.9429 | 0.0163 |
| MCC Threshold | 0.43 | N/A |
| MCC | 0.5814 | N/A |
| F-score Threshold | 0.43 | N/A |
| F-score | 0.815 | N/A |