TargetNet
Q64663
P2X purinoceptor 7
Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Database Links
| Database | Links |
|---|---|
| UniProt | Q64663 |
| PDB | Not available |
| BioGrid | 248286 |
| BindingDB | Q64663 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:29665 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 29665 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9832 | 9.1465 × 10-4 |
| Accuracy | 0.9562 | 0.0029 |
| Sensitivity | 0.95 | 0.0054 |
| Specificity | 0.9619 | 0.0019 |
| BEDROC | 0.9978 | 7.7098 × 10-4 |
| MCC Threshold | 0.436 | N/A |
| MCC | 0.9321 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9646 | N/A |