TargetNet
Q63470
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Function
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1.
Database Links
| Database | Links |
|---|---|
| UniProt | Q63470 |
| PDB | Not available |
| BioGrid | 247295 |
| BindingDB | Q63470 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:25255 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25255 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8622 | 0.0066 |
| Accuracy | 0.7758 | 0.0171 |
| Sensitivity | 0.774 | 0.0228 |
| Specificity | 0.7777 | 0.0213 |
| BEDROC | 0.9624 | 0.014 |
| MCC Threshold | 0.506 | N/A |
| MCC | 0.5955 | N/A |
| F-score Threshold | 0.482 | N/A |
| F-score | 0.8022 | N/A |