TargetNet
Q62758
5-hydroxytryptamine receptor 4
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | Q62758 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q62758 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 9 |
| PharmGKB | Not available |
| KEGG | rno:25324 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25324 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9766 | 0.0039 |
| Accuracy | 0.9473 | 0.0053 |
| Sensitivity | 0.9461 | 0.0101 |
| Specificity | 0.9486 | 0.0045 |
| BEDROC | 0.9974 | 0.0025 |
| MCC Threshold | 0.398 | N/A |
| MCC | 0.9154 | N/A |
| F-score Threshold | 0.398 | N/A |
| F-score | 0.9583 | N/A |