TargetNet
Q5S007
Leucine-rich repeat serine/threonine-protein kinase 2
Function
May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes.
Database Links
| Database | Links |
|---|---|
| UniProt | Q5S007 |
| PDB | 2ZEJ, 3D6T |
| BioGrid | 125700 |
| BindingDB | Q5S007 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2059 |
| PharmGKB | PA134968052 |
| KEGG | hsa:120892 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 120892 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9682 | 0.0015 |
| Accuracy | 0.9288 | 0.0041 |
| Sensitivity | 0.9127 | 0.0073 |
| Specificity | 0.9448 | 0.0048 |
| BEDROC | 0.9998 | 4.3827 × 10-5 |
| MCC Threshold | 0.45 | N/A |
| MCC | 0.8596 | N/A |
| F-score Threshold | 0.45 | N/A |
| F-score | 0.9287 | N/A |