TargetNet
Q3KRE8
Tubulin beta-2B chain
Function
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration.
Database Links
| Database | Links |
|---|---|
| UniProt | Q3KRE8 |
| PDB | Not available |
| BioGrid | 253414 |
| BindingDB | Q3KRE8 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:291081 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 291081 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8357 | 0.0151 |
| Accuracy | 0.7707 | 0.0146 |
| Sensitivity | 0.7987 | 0.0161 |
| Specificity | 0.7411 | 0.0278 |
| BEDROC | 0.9413 | 0.0096 |
| MCC Threshold | 0.504 | N/A |
| MCC | 0.5585 | N/A |
| F-score Threshold | 0.424 | N/A |
| F-score | 0.7963 | N/A |