TargetNet
Q29010
Endothelin-1 receptor
Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q29010 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q29010 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | ssc:397457 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 397457 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.972 | 0.0064 |
| Accuracy | 0.9388 | 0.0072 |
| Sensitivity | 0.9484 | 0.0086 |
| Specificity | 0.9275 | 0.009 |
| BEDROC | 0.9991 | 0.001 |
| MCC Threshold | 0.56 | N/A |
| MCC | 0.902 | N/A |
| F-score Threshold | 0.56 | N/A |
| F-score | 0.9542 | N/A |