TargetNet
Q28156
cGMP-specific 3',5'-cyclic phosphodiesterase
Function
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP.
Database Links
| Database | Links |
|---|---|
| UniProt | Q28156 |
| PDB | 1FL4 |
| BioGrid | Not available |
| BindingDB | Q28156 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:281972 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 281972 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9725 | 0.0025 |
| Accuracy | 0.9465 | 0.0022 |
| Sensitivity | 0.9484 | 0.0043 |
| Specificity | 0.9446 | 0.0031 |
| BEDROC | 0.9962 | 0.0056 |
| MCC Threshold | 0.464 | N/A |
| MCC | 0.9039 | N/A |
| F-score Threshold | 0.464 | N/A |
| F-score | 0.9518 | N/A |