TargetNet
Q16602
Calcitonin gene-related peptide type 1 receptor
Function
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | Q16602 |
| PDB | 3AQF, 3N7P, 3N7R, 3N7S |
| BioGrid | 115498 |
| BindingDB | Q16602 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA26033 |
| KEGG | hsa:10203 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 10203 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9929 | 0.0014 |
| Accuracy | 0.9798 | 0.0013 |
| Sensitivity | 0.9889 | 0.0024 |
| Specificity | 0.9699 | 0.0023 |
| BEDROC | 0.9986 | 0.0015 |
| MCC Threshold | 0.384 | N/A |
| MCC | 0.9614 | N/A |
| F-score Threshold | 0.384 | N/A |
| F-score | 0.9817 | N/A |