Sodium channel protein type 9 subunit alpha
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).
Database | Links |
---|---|
UniProt | Q15858 |
PDB | Not available |
BioGrid | Not available |
BindingDB | Q15858 |
DrugBank | DB00555, DB00281 |
Guide to PHARMACOLOGY | 584 |
PharmGKB | PA35010 |
KEGG | hsa:6335 |
BioCyc | Not available |
Entrez Gene (GeneID) | 6335 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.959 | 0.0024 |
Accuracy | 0.9252 | 0.0048 |
Sensitivity | 0.9419 | 0.0077 |
Specificity | 0.9096 | 0.0056 |
BEDROC | 0.9925 | 0.0076 |
MCC Threshold | 0.328 | N/A |
MCC | 0.8556 | N/A |
F-score Threshold | 0.328 | N/A |
F-score | 0.9266 | N/A |