TargetNet


Q15858

Sodium channel protein type 9 subunit alpha


Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).


Database Links

Database Links
UniProt Q15858
PDB Not available
BioGrid Not available
BindingDB Q15858
DrugBank DB00555, DB00281
Guide to PHARMACOLOGY 584
PharmGKB PA35010
KEGG hsa:6335
BioCyc Not available
Entrez Gene (GeneID) 6335

Chemical Space of the Positive Compounds


Model Performance Metrics

Metric Mean Value Standard Deviation
AUC 0.959 0.0024
Accuracy 0.9252 0.0048
Sensitivity 0.9419 0.0077
Specificity 0.9096 0.0056
BEDROC 0.9925 0.0076
MCC Threshold 0.328 N/A
MCC 0.8556 N/A
F-score Threshold 0.328 N/A
F-score 0.9266 N/A

Downloads

R Model Object

Random Forest model object (.RData)

Download RData

Positive Set

SMILES string + affinity value (.tsv)

Download TSV


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Page generated on: 2014-04-29 14:39:48