Sodium channel protein type 9 subunit alpha
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity).
| Database | Links |
|---|---|
| UniProt | Q15858 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q15858 |
| DrugBank | DB00555, DB00281 |
| Guide to PHARMACOLOGY | 584 |
| PharmGKB | PA35010 |
| KEGG | hsa:6335 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6335 |
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.959 | 0.0024 |
| Accuracy | 0.9252 | 0.0048 |
| Sensitivity | 0.9419 | 0.0077 |
| Specificity | 0.9096 | 0.0056 |
| BEDROC | 0.9925 | 0.0076 |
| MCC Threshold | 0.328 | N/A |
| MCC | 0.8556 | N/A |
| F-score Threshold | 0.328 | N/A |
| F-score | 0.9266 | N/A |