TargetNet
Q15722
Leukotriene B4 receptor 1
Function
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Database Links
| Database | Links |
|---|---|
| UniProt | Q15722 |
| PDB | Not available |
| BioGrid | 107645 |
| BindingDB | Q15722 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 267 |
| PharmGKB | PA30476 |
| KEGG | hsa:1241 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1241 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.986 | 0.0018 |
| Accuracy | 0.949 | 0.0024 |
| Sensitivity | 0.9394 | 0.0062 |
| Specificity | 0.9577 | 0.0056 |
| BEDROC | 0.9998 | 7.494 × 10-5 |
| MCC Threshold | 0.626 | N/A |
| MCC | 0.9134 | N/A |
| F-score Threshold | 0.612 | N/A |
| F-score | 0.9531 | N/A |