TargetNet
Q15661
Tryptase alpha/beta-1
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | Q15661 |
| PDB | 1LTO, 2F9N, 2F9O, 2F9P, 2ZEB, 2ZEC, 4A6L |
| BioGrid | 113029 |
| BindingDB | Q15661 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2424 |
| PharmGKB | PA36698 |
| KEGG | hsa:7177 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7177 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9684 | 0.0041 |
| Accuracy | 0.9226 | 0.0067 |
| Sensitivity | 0.9299 | 0.0071 |
| Specificity | 0.9146 | 0.0131 |
| BEDROC | 0.9992 | 0.0011 |
| MCC Threshold | 0.604 | N/A |
| MCC | 0.88 | N/A |
| F-score Threshold | 0.604 | N/A |
| F-score | 0.9415 | N/A |