TargetNet
Q15078
Cyclin-dependent kinase 5 activator 1
Function
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII.
Database Links
| Database | Links |
|---|---|
| UniProt | Q15078 |
| PDB | 1H4L, 1UNG, 1UNH, 1UNL, 3O0G |
| BioGrid | 114376 |
| BindingDB | Q15078 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA26311 |
| KEGG | hsa:8851 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 8851 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9664 | 0.005 |
| Accuracy | 0.9114 | 0.0043 |
| Sensitivity | 0.9015 | 0.0079 |
| Specificity | 0.9214 | 0.0121 |
| BEDROC | 0.9998 | 3.9954 × 10-5 |
| MCC Threshold | 0.714 | N/A |
| MCC | 0.8313 | N/A |
| F-score Threshold | 0.714 | N/A |
| F-score | 0.9118 | N/A |