TargetNet
Q14833
Metabotropic glutamate receptor 4
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Database Links
| Database | Links |
|---|---|
| UniProt | Q14833 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | Q14833 |
| DrugBank | DB00142 |
| Guide to PHARMACOLOGY | 292 |
| PharmGKB | PA28993 |
| KEGG | hsa:2914 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2914 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8603 | 0.0095 |
| Accuracy | 0.7749 | 0.011 |
| Sensitivity | 0.8417 | 0.0179 |
| Specificity | 0.6919 | 0.0164 |
| BEDROC | 0.9847 | 0.0114 |
| MCC Threshold | 0.398 | N/A |
| MCC | 0.5494 | N/A |
| F-score Threshold | 0.398 | N/A |
| F-score | 0.8172 | N/A |