Sodium channel protein type 5 subunit alpha
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.
Database | Links |
---|---|
UniProt | Q14524 |
PDB | 2KBI, 2L53, 4DCK, 4DJC |
BioGrid | 112236 |
BindingDB | Q14524 |
DrugBank | DB00868, DB01244, DB00564, DB00907, DB00527, DB00280, DB01228, DB00754, DB01195, DB01320, DB00473, DB00192, DB00555, DB00281, DB00532, DB00379, DB01388, DB00680, DB00776, DB00252, DB00750, DB01035, DB01182, DB00908, DB00740, DB01056, DB00661 |
Guide to PHARMACOLOGY | 582 |
PharmGKB | PA304 |
KEGG | hsa:6331 |
BioCyc | Not available |
Entrez Gene (GeneID) | 6331 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.8679 | 0.0086 |
Accuracy | 0.7814 | 0.0111 |
Sensitivity | 0.8434 | 0.0166 |
Specificity | 0.7096 | 0.0186 |
BEDROC | 0.982 | 0.0064 |
MCC Threshold | 0.676 | N/A |
MCC | 0.6029 | N/A |
F-score Threshold | 0.402 | N/A |
F-score | 0.8137 | N/A |